Osteoblast Response to Hydroxyapatite-Functionalized Titanium Implants was presented as part of the PERI-EDU research programme during the 9th Congress of the Polish Dental Association at Ptak Warsaw Expo.
Research question
Study design
The PRISMA-based search covered PubMed, Web of Science, Embase and Scopus. Of 2,016 records, 273 full texts were assessed and 34 studies entered qualitative synthesis.
Main findings
- Nano-hydroxyapatite coatings generally increased osteoblast adhesion, proliferation, differentiation and mineralization.
- The included studies also reported improved bioactivity, osteogenic responses, antibacterial properties and favourable biocompatibility.
- Functionalized coatings incorporated materials such as chitosan, gelatin, magnesium nanoparticles and allicin.
- Observed effects varied with coating composition, fabrication technique and experimental model.
Interpretation
Hydroxyapatite functionalization is a promising surface-engineering strategy, but the diversity of coating formulations and laboratory models limits direct comparisons. Standardized experiments and clinical trials are needed before identifying the most effective composition.
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Funding: This work was co-funded by the European Union under grant agreement No. 2024-1-PL01-KA220-HED-000251208.
Disclaimer: Co-funded by the European Union. Views and opinions expressed are, however, those of the author(s) only and do not necessarily reflect those of the European Union or the Foundation for the Development of the Education System (FRSE). Neither the European Union nor FRSE can be held responsible for them.