Autologous Platelet-Derived Fibrin in Reconstructive Peri-Implantitis Surgery was presented as part of the PERI-EDU research programme during the 9th Congress of the Polish Dental Association at Ptak Warsaw Expo.
Research question
Study design
The search covered Embase, PubMed/MEDLINE, Litmaps, Scopus, Web of Science and CENTRAL through 24 July 2026. Seven eligible reports represented five independent cohorts, including two comparative trials. Minimum follow-up was six months; certainty was assessed with GRADE.
Main findings
- Only two independent comparative trials could be pooled, and their effect directions were inconsistent.
- For probing-depth reduction, the pooled mean difference was 0.15 mm (95% CI -1.10 to 1.39; I²=87.3%).
- For clinical attachment-level gain, the pooled mean difference was 0.46 mm (95% CI -1.54 to 2.46; I²=94.8%).
- Uncontrolled studies reported improvements, but multimodal protocols prevented isolation of the fibrin-matrix effect; no major matrix-specific safety signal emerged.
Interpretation
Autologous fibrin matrices can be incorporated into reconstructive protocols, but current evidence does not demonstrate a reliable additional benefit over established approaches. Certainty is very low, and better standardized randomized trials are required.
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Funding: This work was co-funded by the European Union under grant agreement No. 2024-1-PL01-KA220-HED-000251208.
Disclaimer: Co-funded by the European Union. Views and opinions expressed are, however, those of the author(s) only and do not necessarily reflect those of the European Union or the Foundation for the Development of the Education System (FRSE). Neither the European Union nor FRSE can be held responsible for them.